Kynurenic acid (Standard)
Product Specifications
UNSPSC Description
Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
Target Antigen
Apoptosis; CXCR; Endogenous Metabolite; GPR35 ; iGluR
Type
Reference Standards
Related Pathways
Apoptosis;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/kynurenic-acid-standard.html
Purity
98.87
Solubility
DMSO : 9 mg/mL (ultrasonic;warming)
Smiles
O=C(C1=NC2=CC=CC=C2C(O)=C1)O
Molecular Weight
189.17
References & Citations
[1]Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8.|[2]Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32.|[3]Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100806R/Kynurenic-acid-Standard-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100806R/
Clinical Information
Phase 1
CAS Number
492-27-3
Available Sizes
Curated Selection
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