Pradefovir mesylate
Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir is converted to 9- (2-phosphonylmethoxyethyl) adenine (PMEA) in human liver microsomes with a Km of 60 μM.
Product Specifications
CAS Number
[625095-61-6]
Product Name Alternative
Remofovir mesylate
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Pradefovir_mesylate.html
Concentration
10mM
Purity
99.89
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
NC1=C2N=CN(CCOC[P@]3(OCC[C@@H](C4=CC=CC(Cl)=C4)O3)=O)C2=NC=N1.CS(=O)(O)=O
Molecular Formula
C18H23ClN5O7PS
Molecular Weight
519.90
References & Citations
[1]Lin CC, et al. Metabolic activation of Pradefovir by CYP3A4 and its potential as an inhibitor or inducer. Antimicrob Agents Chemother. 2006 Sep;50 (9) :2926-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
CYP3
Available Sizes
Curated Selection
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