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Cholesteryl hemisuccinate

Product Specifications

UNSPSC Description

Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].

Target Antigen

Apoptosis; DNA/RNA Synthesis; Necroptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis;Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cholesteryl-hemisuccinate.html

Purity

99.70

Solubility

DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 25 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(CCC(O)=O)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C

Molecular Weight

486.73

References & Citations

[1]Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83.|[2]Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-W010800/Cholesteryl-hemisuccinate-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W010800/Cholesteryl-hemisuccinate-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1510-21-0

Available Sizes

Curated Selection

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