Cholesteryl hemisuccinate

Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].

Product Specifications

CAS Number

[1510-21-0]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; DNA/RNA Synthesis; Necroptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cholesteryl-hemisuccinate.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 25 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(CCC(O)=O)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C

Molecular Formula

C31H50O4

Molecular Weight

486.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279 (3) :1470-83.|[2]Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093.