Sempervirine (nitrate)
Sempervirine is an alkaloid derived from Gelsemium elegans Benth.. Sempervirine inhibits the proliferation of hepatocellular carcinoma (HCC) cells and induces apoptosis by regulating Wnt/β-catenin pathway[1].
Product Specifications
CAS Number
17994-15-9
UNSPSC
12352005
Target
Wnt; β-catenin
Type
Natural Products
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sempervirine-nitrate.html
Solubility
10 mM in DMSO
Smiles
O=[N+]([O-])[O-].C12=C(NC3=C2C=C[N+]4=C3C=C(CCCC5)C5=C4)C=CC=C1
Molecular Formula
C19H17N3O3
Molecular Weight
335.36
References & Citations
[1]Yue R, et al. Sempervirine Inhibits Proliferation and Promotes Apoptosis by Regulating Wnt/β-Catenin Pathway in Human Hepatocellular Carcinoma. Front Pharmacol. 2021 Dec 7;12:806091.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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