Atranorin

Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC50 values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions[1][2][3][4][5].

Product Specifications

CAS Number

[479-20-9]

UNSPSC

12352005

Hazard Statement

H317

Target

Akt; AP-1; Bacterial; Endogenous Metabolite; Fungal; PD-1/PD-L1; Ras; STAT; Tim3; Wnt

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/atranorin.html

Purity

99.68

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC1=CC(C)=C(C(OC)=O)C(O)=C1C)C2=C(C)C=C(O)C(C=O)=C2O

Molecular Formula

C19H18O8

Molecular Weight

374.34

Precautions

H317

References & Citations

[1]Zhou R, et al. The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis. Sci Rep. 2017 Aug 15;7 (1) :8136.|[2]Melo MG, et al. Redox properties and cytoprotective actions of atranorin, a lichen secondary metabolite. Toxicol In Vitro. 2011 Mar;25 (2) :462-8.|[3]Semenov K N, et al. Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome. Journal of Molecular Liquids, 2024, 413: 125743.|[4]Barreto R S S, et al. Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents. Revista Brasileira de Farmacognosia, 2013, 23 (2) : 310-319.|[5]Ranković B, et al. The antimicrobial activity of substances derived from the lichens Physcia aipolia, Umbilicaria polyphylla, Parmelia caperata and Hypogymnia physodes. World journal of microbiology and biotechnology, 2008, 24: 1239-1242.