(S) -Benzyl 2-cyclopropyl-2-hydroxyacetate
(S) -Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate reactant in the synthesis of Camptothecin. Camptothecin is an inhibitor of the DNA topoisomerase Topo I, withIC50=679 nM[1][2].
Product Specifications
CAS Number
2414393-48-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-benzyl-2-cyclopropyl-2-hydroxyacetate.html
Purity
98.69
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC=CC=C1)[C@H](C2CC2)O
Molecular Formula
C12H14O3
Molecular Weight
206.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Li Zhen, et al. Camptothecin derivative, and pharmaceutical composition and use thereof. World Intellectual Property Organization, WO2023020605 A1. 2023-02-23.|[2]Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem. 2013;63:746-757.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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