O-Phospho-L-serine

O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8) ; O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].

Product Specifications

CAS Number

[407-41-0]

Product Name Alternative

L-Serine O-phosphate; L-SOP

UNSPSC

12352211

Hazard Statement

H314

Target

Endogenous Metabolite; mGluR

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/O-Phospho-L-serine.html

Purity

99.90

Solubility

DMSO : < 1 mg/mL|H2O : 25 mg/mL (ultrasonic)

Smiles

OP(OC[C@@H](C(O)=O)N)(O)=O

Molecular Formula

C3H8NO6P

Molecular Weight

185.07

Precautions

H314

References & Citations

[1]Kang HJ, et al. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30;290 (5) :2870-8.|[2]Kang HJ, et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24;289 (43) :29961-74.|[3]Bailey TJ, et al. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res. 2010 Nov;91 (5) :601-12.