PROTAC HDAC8 Degrader-1

Degrader-1 (compound Z16) is a potent and selective HDAC8 PROTAC degrader with an DC50 of 0.27 nM in A549 cells[1].

Product Specifications

UNSPSC

12352211

Target

HDAC; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-hdac8-degrader-1.html

Smiles

O=C(NCC1=CC=C(C(NNCCCCCC)=O)C=C1)CN2CCC(C3=CC=C(NC(CC4)C(NC4=O)=O)C=C3)CC2

Molecular Formula

C32H44N6O4

Molecular Weight

576.73

References & Citations

[1]Zhao C, et al. Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors. J Med Chem. 2024 Aug 1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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