PROTAC HDAC8 Degrader-1
Degrader-1 (compound Z16) is a potent and selective HDAC8 PROTAC degrader with an DC50 of 0.27 nM in A549 cells[1].
Product Specifications
UNSPSC
12352211
Target
HDAC; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-hdac8-degrader-1.html
Smiles
O=C(NCC1=CC=C(C(NNCCCCCC)=O)C=C1)CN2CCC(C3=CC=C(NC(CC4)C(NC4=O)=O)C=C3)CC2
Molecular Formula
C32H44N6O4
Molecular Weight
576.73
References & Citations
[1]Zhao C, et al. Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors. J Med Chem. 2024 Aug 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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