Asunaprevir
Product Specifications
UNSPSC Description
Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC50 of 0.2 nM-3.5 nM[1]. Asunaprevir inhibits SARS-CoV-2 3CLpro activity[5].
Target Antigen
HCV; HCV Protease; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Asunaprevir.html
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : 20 mg/mL (ultrasonic)
Smiles
ClC1=CC=C2C(C(O[C@H]3CN(C([C@@H](NC(OC(C)(C)C)=O)C(C)(C)C)=O)[C@H](C(N[C@@]4(C(NS(C5CC5)(=O)=O)=O)[C@H](C=C)C4)=O)C3)=NC=C2OC)=C1
Molecular Weight
748.29
References & Citations
[1]Pelosi LA, et al. Effect on HCV Replication by Combinations of Direct Acting Antivirals Including NS5A Inhibitor BMS-790052. 
Antimicrob Agents Chemother. 2012 Jul 30.|[2]McPhee F, et al. Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032).
Antimicrob Agents Chemother. 2012 Aug 6.|[3]McPhee F, et al. Resistance analysis of the hepatitis C virus NS3 protease inhibitor asunaprevir.
Antimicrob Agents Chemother. 2012 Jul;56(7):3670-81.|[4]Pasquinelli C, et al. Single- and multiple-ascending-dose studies of the NS3 protease inhibitor asunaprevir in subjects with or without chronic hepatitis C.
 Antimicrob Agents Chemother. 2012 Apr;56(4):1838-44.|[5]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14434/Asunaprevir-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14434/Asunaprevir-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
630420-16-5
Available Sizes
Curated Selection
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