MYF-01-37
MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction[1].
Product Specifications
CAS Number
[2416417-65-5]
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/myf-01-37.html
Concentration
10mM
Purity
99.44
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(C)(C1)NC2=CC=CC(C(F)(F)F)=C2)C=C
Molecular Formula
C15H17F3N2O
Molecular Weight
298.30
References & Citations
[1]Kari J Kurppa, et al. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 2020 Jan 13;37 (1) :104-122.e12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP/TAZ-TEAD
Available Sizes
Curated Selection
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