Bayer-18

Bayer-18 is an inhibitor for TYK2. Bayer-18 inhibits the viability of ALCL cell K299, SR786, Mac1 and Mac2a with IC50 of 2-3 µM, and induces apoptosis in K299 and SR786[1].

Product Specifications

CAS Number

[1251752-12-1]

UNSPSC

12352005

Target

Apoptosis; JAK

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bayer-18.html

Purity

99.51

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC(C)(C)C)NC1=CC=CC(NC2=NC=C(C(NC(C)(CO)C)=N2)F)=C1

Molecular Formula

C19H27FN6O2

Molecular Weight

390.46

References & Citations

[1]Prutsch N, et al., Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia. 2019 Mar;33 (3) :696-709. doi: 10.1038/s41375-018-0239-1. Epub 2018 Aug 21. Erratum in: Leukemia. 2020 Nov;34 (11) :3105.