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Amodiaquine (dihydrochloride dihydrate) (Standard)

Amodiaquine (dihydrochloride dihydrate) (Standard) is the analytical standard of Amodiaquine (dihydrochloride dihydrate) . This product is intended for research and analytical applications. Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

Product Specifications

CAS Number

6398-98-7

Product Name Alternative

Amodiaquin (dihydrochloride dihydrate) (Standard)

UNSPSC

12352005

Target

Histone Methyltransferase; Nuclear Hormone Receptor 4A/NR4A; Parasite; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Epigenetics; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/amodiaquine-dihydrochloride-dihydrate-standard.html

Purity

99.89

Smiles

OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CN(CC)CC.Cl.Cl.O.O

Molecular Formula

C20H22ClN3O.2H2O.2HCl

Molecular Weight

464.81

References & Citations

[1]Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112 (28) :8756-61.|[2]Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54.|[3]Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558 (1-3) :179-84.|[4]M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3 (5) :833-8.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed and dry storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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