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(Glu2)-TRH

Product Specifications

UNSPSC Description

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].

Target Antigen

Endogenous Metabolite; Thyroid Hormone Receptor

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glu2-trh.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1CCC(N1)=O)N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(N)=O)=O

Molecular Weight

354.36

References & Citations

[1]Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P3960/Glu2-TRH-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P3960/Glu2-TRH-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

85541-78-2

Available Sizes

Curated Selection

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