XY039
XY039 (compound 13e) is a RORγ inverse agonist with the IC50 of 0.55 μM. XY039 induces cell apoptosis and shows antiproliferative activity in vivoand in vitro[1].
Product Specifications
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xy039.html
Smiles
O=S(C1=CC=C(F)C=C1F)(NC2=CC3=C(C=C2)CCCN3S(=O)(CC4=CC=C(C(F)(F)F)C=C4)=O)=O
Molecular Formula
C23H19F5N2O4S2
Molecular Weight
546.53
References & Citations
[1]Wu XS, et al. Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer. Acta Pharmacol Sin. Published online May 2, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ
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