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XY039

XY039 (compound 13e) is a RORγ inverse agonist with the IC50 of 0.55 μM. XY039 induces cell apoptosis and shows antiproliferative activity in vivoand in vitro[1].

Product Specifications

UNSPSC

12352005

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xy039.html

Smiles

O=S(C1=CC=C(F)C=C1F)(NC2=CC3=C(C=C2)CCCN3S(=O)(CC4=CC=C(C(F)(F)F)C=C4)=O)=O

Molecular Formula

C23H19F5N2O4S2

Molecular Weight

546.53

References & Citations

[1]Wu XS, et al. Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer. Acta Pharmacol Sin. Published online May 2, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

RORγ

Frequently Asked Questions

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