4-Hydroxytamoxifen

4-Hydroxytamoxifen ((Z) -4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM) . 4-Hydroxytamoxifen ((Z) -4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen (HY-13757A) in vivo and can be used to induce gene knockout in transgenic mice expressing CreER[1][2][3][4].

Product Specifications

CAS Number

[68047-06-3]

Product Name Alternative

(Z) -4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z) -Afimoxifene

UNSPSC

12352005

Hazard Statement

H305, H360

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-Hydroxytamoxifen.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 20 mg/mL (ultrasonic)

Smiles

CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=C(O)C=C3

Molecular Formula

C26H29NO2

Molecular Weight

387.52

Precautions

H305, H360

References & Citations

[1]Jordan VC, et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol. 1977 Nov;75 (2) :305-16.|[2]Davis KM, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11 (5) :316-8.|[3]Kuo YM, et al. 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. J Neurochem. 2003 Dec;87 (6) :1436-43.|[4]Zhang J, et al. Drug Inducible CRISPR/Cas Systems. Comput Struct Biotechnol J. 2019;17:1171-1177.