CHPG
Product Specifications
UNSPSC Description
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].
Target Antigen
Akt; ERK; mGluR; NF-κB
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway;Neuronal Signaling;NF-κB;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/chpg.html
Purity
99.0
Solubility
1M NaOH : 25 mg/mL (ultrasonic;adjust pH to 11 with NaOH)|DMSO : < 1 mg/mL (ultrasonic)
Smiles
O=C(O)C(N)C1=CC(O)=CC=C1Cl
Molecular Weight
201.609
References & Citations
[1]Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO<sub>2</sub>-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.|[2]Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101364/CHPG-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101364/CHPG-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
170846-74-9
Available Sizes
Curated Selection
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