Resomelagon
Resomelagon (AP1189) is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3. Resomelagon induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon has anti-inflammatory activity. Resomelagon can be used for obesity and chronic inflammation research[1][2].
Product Specifications
CAS Number
1809420-71-0
Product Name Alternative
AP1189
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/resomelagon.html
Purity
98.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N=C(N)N/N=C/C=C/C1=CC=CN1C2=C(C=CC=C2)[N+]([O-])=O
Molecular Formula
C14H14N6O2
Molecular Weight
298.30
References & Citations
[1]Montero-Melendez T, et, al. Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. J Immunol. 2015 Apr 1;194 (7) :3381-8.|[2]WHO Drug Information. International Nonproprietary Names for Pharmaceutical
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MC1R; MC3R
Available Sizes
Frequently Asked Questions
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