[MePhe8, Sar9] Substance P

[MePhe8, Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (HY-P0201) . Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS[1].

Product Specifications

CAS Number

[77128-76-8]

Product Name Alternative

[MePhe8-MeGly9] Substance P

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mephe8-sar9-substance-p.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(CCC1)C([C@@H](N)CCCNC(N)=N)=O)N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N(C)[C@H](C(N(C)CC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)=O)=O

Molecular Formula

C65H102N18O13S

Molecular Weight

1375.68

References & Citations

[1]Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6 (5) :509-24.