Honokiol
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].
Product Specifications
CAS Number
35354-74-6
Product Name Alternative
NSC 293100
UNSPSC
12352005
Hazard Statement
H318, H410
Target
Akt; Autophagy; ERK; HCV
Type
Natural Products
Related Pathways
Anti-infection; Autophagy; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/honokiol.html
Purity
99.94
Solubility
DMSO : ≥ 50 mg/mL
Smiles
OC1=C(CC=C)C=C(C2=CC(CC=C)=CC=C2O)C=C1
Molecular Formula
C18H18O2
Molecular Weight
266.33
Precautions
H318, H410
References & Citations
[1]Chang KH, et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6 (5) :1435-1438.|[2]Godugu C, et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC) . Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219|[3]Lee TY, et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002|[4]Zhai H, et al. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2) . Eur J Pharmacol. 2005 Jun 1;516 (2) :112-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
ERK1; ERK2
Available Sizes
Frequently Asked Questions
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