Honokiol

Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].

Product Specifications

CAS Number

[35354-74-6]

Product Name Alternative

NSC 293100

UNSPSC

12352005

Hazard Statement

H318, H410

Target

Akt; Autophagy; ERK; HCV

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/honokiol.html

Purity

99.94

Solubility

DMSO : ≥ 50 mg/mL

Smiles

OC1=C(CC=C)C=C(C2=CC(CC=C)=CC=C2O)C=C1

Molecular Formula

C18H18O2

Molecular Weight

266.33

Precautions

H318, H410

References & Citations

[1]Chang KH, et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6 (5) :1435-1438.|[2]Godugu C, et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC) . Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219|[3]Lee TY, et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002|[4]Zhai H, et al. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2) . Eur J Pharmacol. 2005 Jun 1;516 (2) :112-7.