VEGF Recombinant Antibody [Bevacizumab] (OAAV00400)

Product Specifications

Gene Name

Interleukin 6 receptor

Gene Aliases

CD126; CD126 antigen; gp80; HIES5; IL-1Ra; IL-6 receptor subunit alpha; IL6Q; IL6QTL; IL-6R; IL-6R 1; IL-6R-1; IL6RA; IL-6RA; IL6RQ; interleukin-6 receptor subunit alpha; membrane glycoprotein 80.

Gene ID

3570

Accession Number

NP_000556.1ÃƒÂ¯Ã‚Â»Ã‚Â¿

Reactivity

Human

Immunogen

The original antibody was generated by CDR grafting of mouse PM-1 antibody onto human REI and NEW framework regions to create rhPM-1.

Target

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Clonality

Recombinant Monoclonal

Clone

RhPM-1 (Tocilizumab)

Type

Recombinant Monoclonal Antibody

Purification

Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Dilution

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

Format

PBS with 0.02% Proclin 300.

Reconstitution

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

Fragment

IgG, kappa

Specificity

Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.