CGP52432
Product Specifications
UNSPSC Description
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
Target Antigen
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CGP52432.html
Purity
98.16
Solubility
DMSO : 5 mg/mL (ultrasonic;warming)|H2O : 4 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=P(C(OCC)OCC)(CCCNCC1=CC=C(Cl)C(Cl)=C1)O
Molecular Weight
384.24
References & Citations
[1]Lanza M, et al. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Eur J Pharmacol. 1993 Jun 24;237(2-3):191-5.|[2]Sweeney FF, et al. Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice. Neuropharmacology. 2014 Jun;81:303-10.|[3]Kobuchi S, et al. Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats. Clin Exp Pharmacol Physiol. 2015 Mar;42(3):278-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103531/CGP52432-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103531/CGP52432-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
139667-74-6
Available Sizes
Curated Selection
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