CGP52432

CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.

Product Specifications

CAS Number

[139667-74-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CGP52432.html

Purity

98.57

Solubility

DMSO : 5 mg/mL (ultrasonic; warming) |H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=P(C(OCC)OCC)(CCCNCC1=CC=C(Cl)C(Cl)=C1)O

Molecular Formula

C15H24Cl2NO4P

Molecular Weight

384.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Lanza M, et al. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Eur J Pharmacol. 1993 Jun 24;237 (2-3) :191-5.|[2]Sweeney FF, et al. Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice. Neuropharmacology. 2014 Jun;81:303-10.|[3]Kobuchi S, et al. Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats. Clin Exp Pharmacol Physiol. 2015 Mar;42 (3) :278-86.