CGP52432
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
Product Specifications
CAS Number
[139667-74-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CGP52432.html
Purity
98.57
Solubility
DMSO : 5 mg/mL (ultrasonic; warming) |H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=P(C(OCC)OCC)(CCCNCC1=CC=C(Cl)C(Cl)=C1)O
Molecular Formula
C15H24Cl2NO4P
Molecular Weight
384.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Lanza M, et al. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Eur J Pharmacol. 1993 Jun 24;237 (2-3) :191-5.|[2]Sweeney FF, et al. Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice. Neuropharmacology. 2014 Jun;81:303-10.|[3]Kobuchi S, et al. Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats. Clin Exp Pharmacol Physiol. 2015 Mar;42 (3) :278-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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