EGFR Recombinant Antibody [S3 12D] (OAAV00318)
Product Specifications
Gene Name
Integrin subunit alpha 2b
Gene Aliases
AlphaIIb protein; BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPalpha IIb; GPIIb; GT; GT1; GTA; HPA3; integrin alpha-IIb; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) ; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/IIIa complex; platelet membrane glycoprotein IIb; platelet-specific antigen BAK; PPP1R93; protein phosphatase 1, regulatory subunit 93.
Gene ID
3674
Swiss Prot
P01135
Accession Number
NP_000410.2
Reactivity
Human
Immunogen
Human blood platelets.
Clonality
Recombinant Monoclonal
Clone
1000000
Type
Recombinant Monoclonal Antibody
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Dilution
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Format
PBS with 0.02% Proclin 300.
Reconstitution
Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
Fragment
IgG2a, kappa
Specificity
The antibody binds to GPIIb/IIIa with an affinity (Kd) of 16.2±6 nM. The antibody completely inhibits platelet aggregation at 7.8 µg/ml.
NCBI Gene Symbol
ITGA2B
Host or Source
Mouse
Protein Name
Integrin alpha-IIb
Gene Name URL
ITGA2B
Nucleotide Accession Number
NM_000419.4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
