TrkA Recombinant Antibody [MNAC13] (OAAV00308)

Product Specifications

Gene Name

Beta-secretase 2

Gene Aliases

56 kDa aspartic-like protease; AEPLC; ALP56; ASP1; ASP21; Aspartic-like protease 56 kDa; aspartyl protease 1; BAE2; beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin-1; membrane-associated aspartic protease 1; SLCO3A1/BACE2 fusion; theta-secretase; transmembrane aspartic proteinase Asp1.

Gene ID

25825

Swiss Prot

P00533

Accession Number

NP_036237.2ÃƒÂ¯Ã‚Â»Ã‚Â¿

Reactivity

Human

Immunogen

Human BACE2 244-333.

Target

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Clonality

Recombinant Monoclonal

Clone

44935

Type

Recombinant Monoclonal Antibody

Purification

Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Dilution

Responsible for the proteolytic processing of the amyloid precursor protein (APP) . Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.