IL-18 Recombinant Antibody [SAIC-24B-4] (OAAV00262)
Product Specifications
Gene Name
Reticulon 4 receptor like 2
Gene Aliases
NgR2; NGRH1; nogo receptor-like 3; Nogo-66 receptor homolog 1; nogo-66 receptor-related protein 2; reticulon-4 receptor-like 2.
Gene ID
349667
Swiss Prot
P19429
Accession Number
NP_848665.1
Immunogen
(His) 6-tagged fragment of rat NgR2 (amino acids 279-420) .
Clonality
Recombinant Monoclonal
Clone
P14
Type
Recombinant Monoclonal Antibody
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Dilution
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity) . Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity) . Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200) . Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200) .
Format
PBS with 0.02% Proclin 300.
Reconstitution
Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
Fragment
IgG, kappa
Specificity
The antibody binds to human NgR2 with a Kd of 2.3 nM and to rat NgR2 with a Kd of 0.48 nM (bivalent binding) .
NCBI Gene Symbol
RTN4RL2
Host or Source
Rabbit
Protein Name
Reticulon-4 receptor-like 2
Gene Name URL
RTN4RL2
Nucleotide Accession Number
NM_178570.2
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