IL-18 Recombinant Antibody [SAIC-24B-4] (OAAV00261)
Product Specifications
Gene Name
Reticulon 4 receptor like 1
Gene Aliases
NgR3; NGRH2; nogo receptor-like 2; Nogo-66 receptor homolog 2; Nogo-66 receptor-related protein 3; reticulon-4 receptor-like 1.
Gene ID
146760
Swiss Prot
P19429
Accession Number
NP_848663.1
Immunogen
(His) 6-tagged fragment of rat NgR1 (amino acids 278-473) .
Clonality
Recombinant Monoclonal
Clone
M5
Type
Recombinant Monoclonal Antibody
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Dilution
Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity) . Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200) . Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200) .
Format
PBS with 0.02% Proclin 300.
Reconstitution
Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
Fragment
IgG, kappa
Specificity
The antibody binds to human and rat NgR1 with a Kd of 2.9 nM for both species (bivalent binding) .
NCBI Gene Symbol
RTN4RL1
Host or Source
Rabbit
Protein Name
Reticulon-4 receptor-like 1
Gene Name URL
RTN4RL1
Nucleotide Accession Number
NM_178568.3
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