Unknown Specificity (Isotype control) Recombinant Antibody [MOPC-21] (OAAV00179)

Product Specifications

Gene Name

Tyrosinase related protein 1

Gene Aliases

5,6-dihydroxyindole-2-carboxylic acid oxidase; b-PROTEIN; CAS2; catalase B; CATB; DHICA oxidase; glycoprotein 75; GP75; melanoma antigen gp75; OCA3; TRP; TRP1; Tyrosinase-related protein 1; TYRP.

Gene ID

7306

Swiss Prot

P15391

Accession Number

NP_000541.1ÃƒÂ¯Ã‚Â»Ã‚Â¿

Reactivity

Human

Immunogen

70-75 kDa pigmentation-associated glycoprotein in human melanoma cell lines.

Target

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Clonality

Recombinant Monoclonal

Clone

TA99

Type

Monoclonal Antibody

Purification

Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Dilution

Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu (2+) ions (PubMed:28661582) . May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458) . Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity) .

Format

PBS with 0.02% Proclin 300.

Reconstitution

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

Fragment

IgG, kappa

Specificity

Binds Tyrosinase-related protein-1 (TRP-1), a 70-75k enzyme located in melanocytes, which are specialized cells that produce a pigment called melanin, helping to stabilize tyrosinase, which is the enzyme responsible for the first step in melanin production and determine the shape of melanosomes, which are the structures in melanocytes where melanin is produced.