Unknown Specificity (Isotype control) Recombinant Antibody [MOPC-21] (OAAV00178)
Product Specifications
Gene Name
Tyrosinase related protein 1
Gene Aliases
5,6-dihydroxyindole-2-carboxylic acid oxidase; b-PROTEIN; CAS2; catalase B; CATB; DHICA oxidase; glycoprotein 75; GP75; melanoma antigen gp75; OCA3; TRP; TRP1; Tyrosinase-related protein 1; TYRP.
Gene ID
7306
Swiss Prot
P01730
Accession Number
NP_000541.1
Reactivity
Human
Immunogen
70-75 kDa pigmentation-associated glycoprotein in human melanoma cell lines.
Clonality
Recombinant Monoclonal
Clone
TA99
Type
Monoclonal Antibody
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Dilution
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu (2+) ions (PubMed:28661582) . May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458) . Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity) .
Format
PBS with 0.02% Proclin 300.
Reconstitution
Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
Fragment
IgG2a, kappa
Specificity
Binds Tyrosinase-related protein-1 (TRP-1), a 70-75k enzyme located in melanocytes, which are specialized cells that produce a pigment called melanin, helping to stabilize tyrosinase, which is the enzyme responsible for the first step in melanin production and determine the shape of melanosomes, which are the structures in melanocytes where melanin is produced.
NCBI Gene Symbol
TYRP1
Host or Source
Mouse
Protein Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
Gene Name URL
TYRP1
Nucleotide Accession Number
NM_000550.2
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