CD16/CD32 Recombinant Antibody [2.4G2] (OAAV00084)

AI528646; CD32; F630109E10Rik; fc gamma receptor IIB; Fc gamma RIIB; Fc[g]; Fc[g]RII; Fcg; Fcgamm; fc-gamma RII; Fc-gamma RIII; Fc-gamma-RII; fc-gamma-RIIB; FcgammaRIIB; Fcgr; Fcgr2; Fcgr2a; FcgRII; Fcr-; Fcr-2; Fcr-3; fcRII; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; Ly-1; Ly-17; LyM-; LyM-1; Ly-m2; Ly-m20; lymphocyte antigen 17.

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b (PubMed:17558411) . Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (PubMed:18097064) .|Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.

This antibody binds to an epitope on the extracellular domains of the mouse FcγIII and FcγII, thereby inhibiting their ability to bind antibodies via their Fc region._x005F receptors. Also binding the FcγI receptor (CD64) via its Fc domain.