Amyloid Beta Peptide 1-40 Monomers
Human Synthetic Amyloid Beta Peptide 1-40 Monomers
Product Specifications
Background
Amyloid Beta 1-40 peptide (Aβ40) is a major isoform implicated in Alzheimer’s disease, contributing to plaque formation and neurotoxicity despite being less aggregation-prone than Aβ42. Aβ40’s interaction with neural membranes and metal ions accelerates oligomerization and oxidative stress, disrupting neuronal function. Genetic factors like PLXNB1 influence glial responses and plaque morphology, modulating neuroinflammation and disease progression. Our Amyloid Beta Peptide 1-40 Monomers are produced synthetically and presents as a monomeric band at the expected molecular weight (MW) on SDS-PAGE via Coomassie Stain and Western Blot.
Product Name Alternative
Aβ 1-40, AB40, Amyloid beta 1-40, Beta-amyloid peptide (1-40), Amyloid-beta A4 protein, Amyloid precursor protein (APP), Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide (CVAP), Protease nexin-II (PN-II), PreA4, Peptidase nexin-II, APP40, BAPP40, BetaAPP40
UNSPSC
12352202
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
351
Swiss Prot
P05067
Expression System
Synthetic
Conjugation
No Tag
Nature
Synthetic
Applications
WB | SDS-PAGE
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Amyloid
Limit Of Detection
Certified > 98% pure using mass spec and HPLC
Concentration
1 mg/mL
Purity
> 98%
Buffer
PB pH7.4, 10mM NaCl
Molecular Weight
4.5 kDa
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Shipping Conditions
Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Storage Conditions
-80ºC
Protein Length
40 amino acids
Background Reference 01
1. Ghosh, P., Narang, K., & Iyer, P. K. (2024) . Role of Amyloid Beta in Neurodegeneration and Therapeutic Strategies for Neuroprotection. Methods in molecular biology (Clifton, N.J.), 2761, 337–354. https://doi.org/10.1007/978-1-0716-3662-6_25 2. Huang, Y., et al. (2024) . Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease. Nature Neuroscience, 27, 1489–1504. https://doi.org/10.1038/s41593-024-01664-w 3. Mirdha L. (2024) . Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition. The Journal of membrane biology, 257 (3-4), 151–164. https://doi.org/10.1007/s00232-024-00314-3
AA Sequence
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Immunogen Species
Human
Curated Selection
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