Tau (K18) Wild-Type Pre-formed Fibrils

Tauopathies are a class of neurodegenerative diseases characterized by the pathological aggregation of tau protein into insoluble fibrils that disrupt neuronal function. The K18 fragment, which includes the four microtubule-binding repeat domains of tau, is frequently used in experimental models due to its propensity to form fibrillar aggregates. Kumar & Udgaonkar (2022) observed that tau K18 wildtype fibrils exhibit distinct structural features compared to mutant forms, with the wildtype fibrils catalyzing aggregation of monomeric tau more efficiently. StressMarq’s Human Recombinant Tau (K18) Wild-Type Pre-Formed Fibrils have been demonstrated to seed monomers in an in-vitro ThT seeding assay.

Tau, Microtubule-associated Tau, Microtubule-associated protein Tau, MAPT, MAP, Tau-441, Tau-412, Tau-381, Tau-352, Paired Helical Filament-Tau, PHF-Tau, Neurofibrillary Tangle Tau, G Beta/Gamma Subunit-Interacting Factor 1, Isoform 4, Tubulin-associated unit

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