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KChIP3 Antibody, Clone X12: APC

Rabbit Anti-Rat KChIP3 Recombinant Monoclonal IgG Kappa

Product Specifications

Background

KChIP3, also known as DREAM or calsenilin, is a neuronal calcium-binding protein that plays a central role in regulating gene expression, potassium channel activity, and neurodegenerative signaling. It modulates Kv4 potassium channels, thereby influencing neuronal excitability and synaptic plasticity, which are key processes disrupted in neurodegenerative diseases such as Alzheimer’s. In the nucleus, KChIP3 acts as a calcium-dependent transcriptional repressor, regulating genes like prodynorphin that are involved in pain signaling and neuroprotection. Its interaction with presenilin proteins affects amyloid precursor protein processing, linking KChIP3 to Alzheimer’s disease pathology. Our recombinant monoclonal antibody targeting rat KChIP3 has been shown to enable high-specificity detection in rodent brain lysates and in overexpression lysates

Product Name Alternative

KChIP3 Antibody, Kv channel-interacting protein 3 Antibody, Kcnip3 Antibody, A-type potassium channel modulatory protein 3 Antibody, Calsenilin Antibody, Csen Antibody, DRE-agonist modulator Antibody, Dream Antibody

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

65199

Swiss Prot

Q9JM47

Accession Number

NP_115851.1

Host

Rabbit

Immunogen

Fusion protein, AA #1-256 (full length) of rat KChIP3.

Clone

X12

Conjugation

APC

Tissue Specificity

Brain

Type

Recombinant Monoclonal

Applications

WB

Field of Research

Neuroscience | Ion Channels | Potassium Channels | Voltage-Gated Potassium Channel-Interacting Proteins | Cell Signaling | Cardiovascular System | Blood

Purification

AmMagTM Ultra AT Protein A MagBeads

Limit Of Detection

1 µg/ml was sufficient for detection of KChIP3 on Rat Brain Membrane lysate.

Concentration

1mg/mL

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/APC-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects full length KChIP3. Does not cross-react with KChiP1, KChiP2, or KChiP4.

Background Reference 01

1. Wang, S. et al. (2002) . Kinetic properties of Kv4.3 and their modulation by KChIP2b. Biochem Biophys Res Commun, 295 (2), 223-229. https://doi.org/10.1016/S0006-291X (02) 00658-7 2. Van Vickle, G.D., Esh, C.L., Kokjohn, T.A. et al. Presenilin-1 280Glu→Ala Mutation Alters C-Terminal APP Processing Yielding Longer Aβ Peptides: Implications for Alzheimer’s Disease. Mol Med 14, 184–194 (2008) . https://doi.org/10.2119/2007-00094.VanVickle 3. Zaidi, N. F., Kuplast, K. G., Washicosky, K. J., Kajiwara, Y., Buxbaum, J. D., & Wasco, W. (2006) . Calsenilin interacts with transcriptional co-repressor C-terminal binding protein (s) . Journal of neurochemistry, 98 (4), 1290–1301. https://doi.org/10.1111/j.1471-4159.2006.03972.x

Species

Human | Mouse | Rat

Location

Cytoplasm, Cell membrane, Endoplasmic reticulum, Golgi apparatus, Nucleus

Isotype

IgG Kappa

Immunogen Species

Rat

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