KChIP3 Antibody, Clone X12: APC

KChIP3, also known as DREAM or calsenilin, is a neuronal calcium-binding protein that plays a central role in regulating gene expression, potassium channel activity, and neurodegenerative signaling. It modulates Kv4 potassium channels, thereby influencing neuronal excitability and synaptic plasticity, which are key processes disrupted in neurodegenerative diseases such as Alzheimer’s. In the nucleus, KChIP3 acts as a calcium-dependent transcriptional repressor, regulating genes like prodynorphin that are involved in pain signaling and neuroprotection. Its interaction with presenilin proteins affects amyloid precursor protein processing, linking KChIP3 to Alzheimer’s disease pathology. Our recombinant monoclonal antibody targeting rat KChIP3 has been shown to enable high-specificity detection in rodent brain lysates and in overexpression lysates

KChIP3 Antibody, Kv channel-interacting protein 3 Antibody, Kcnip3 Antibody, A-type potassium channel modulatory protein 3 Antibody, Calsenilin Antibody, Csen Antibody, DRE-agonist modulator Antibody, Dream Antibody

Neuroscience | Ion Channels | Potassium Channels | Voltage-Gated Potassium Channel-Interacting Proteins | Cell Signaling | Cardiovascular System | Blood

1. Wang, S. et al. (2002) . Kinetic properties of Kv4.3 and their modulation by KChIP2b. Biochem Biophys Res Commun, 295 (2), 223-229. https://doi.org/10.1016/S0006-291X (02) 00658-7 2. Van Vickle, G.D., Esh, C.L., Kokjohn, T.A. et al. Presenilin-1 280Glu→Ala Mutation Alters C-Terminal APP Processing Yielding Longer Aβ Peptides: Implications for Alzheimer’s Disease. Mol Med 14, 184–194 (2008) . https://doi.org/10.2119/2007-00094.VanVickle 3. Zaidi, N. F., Kuplast, K. G., Washicosky, K. J., Kajiwara, Y., Buxbaum, J. D., & Wasco, W. (2006) . Calsenilin interacts with transcriptional co-repressor C-terminal binding protein (s) . Journal of neurochemistry, 98 (4), 1290–1301. https://doi.org/10.1111/j.1471-4159.2006.03972.x