Kv1.2 Antibody, Clone C25: ATTO 594

Kv1.2, encoded by the KCNA2 gene, is a voltage-gated potassium channel subunit that plays a critical role in regulating neuronal excitability and synaptic transmission. Beyond its significance as a biophysical model for ion channel gating, Kv1.2 has emerged as a key modulator of brain function, with growing evidence linking KCNA2 mutations to a range of neurological disorders, including epilepsy, ataxia, and neurodevelopmental syndromes. A landmark crystallographic study resolved the Kv1.2 channel structure at 2.9 Å, revealing the open activation gate and tetrameric subunit architecture. This structural insight has become foundational for understanding the gating mechanisms of voltage-gated ion channels across the nervous system. Functionally, Kv1.2 channels are expressed in axons and presynaptic terminals, where they shape action potential propagation and modulate neurotransmitter release. By influencing both the timing and strength of synaptic communication, Kv1.2 contributes to the fine-tuning of neural circuit dynamics essential for cognition, motor control, and sensory processing. In the context of neurodegenerative disease, dysregulation of Kv1.2 activity may lead to aberrant neuronal firing, excitotoxicity, and impaired network stability—hallmarks of conditions such as Alzheimer’s disease and multiple sclerosis. As such, Kv1.2 is increasingly recognized as a potential therapeutic target for restoring electrical balance in diseased neural circuits. Due to its recombinant nature, our Human Kv1.2 Recombinant Monoclonal IgG offers high specificity and reproducibility, making it ideal for applications in immunohistochemistry, western blotting, and ion channel research.

WB (1:1000), IHC (1:100), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.; optimal dilutions for assays should be determined by the user.

1. Baronas, V. A., Yang, R. Y., & Kurata, H. T. (2017) . Extracellular redox sensitivity of Kv1.2 potassium channels. Scientific Reports, 7, 9145. https://doi.org/10.1038/s41598-017-08718-z 2. Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) . Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science, 309 (5736), 897–903. DOI: 10.1126/science.1116269 3. Kole, M. H. P., Letzkus, J. J., & Stuart, G. J. (2007) . Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron, 55 (4), 633–647. DOI: 10.1016/j.neuron.2007.07.031

Cell membrane, Cell projection, Synapse, Endoplasmic reticulum membrane, Lamellipodium membrane, Synaptosome, Presynaptic membrane, Dendrite, Paranodal septate junction