GFP Antibody, Clone H24

Green fluorescent protein (GFP) is a 27 kDa reporter protein originally isolated from the jellyfish Aequorea victoria. It emits bright green fluorescence when exposed to ultraviolet or blue light, making it an indispensable tool in molecular and cellular neuroscience. GFP enables real-time visualization of gene expression, protein localization, and cellular dynamics in live cells and tissues without the need for additional substrates or cofactors. In neurodegenerative disease research, GFP is widely used to track neuronal morphology, monitor synaptic changes, and study the progression of protein aggregation in models of Alzheimer’s, Parkinson’s, and Huntington’s disease. By fusing GFP to disease-relevant proteins such as tau, α-synuclein, or huntingtin, researchers can observe pathological processes in real time and assess the efficacy of therapeutic interventions. The recombinant nature of GFP ensures high specificity, consistent expression, and minimal cytotoxicity, which enhances reproducibility across experimental systems. Additionally, its compatibility with advanced imaging techniques—including confocal and two-photon microscopy—makes GFP a cornerstone in the study of neural circuits and neurodegenerative mechanisms. As a genetically encoded fluorescent marker, GFP continues to drive innovation in neuroscience by enabling precise, dynamic, and non-invasive investigation of cellular processes underlying brain function and disease.

1. Prasher, D. C., Eckenrode, V. K., Ward, W. W., Prendergast, F. G., & Cormier, M. J. (1992) . Primary structure of the Aequorea victoria green-fluorescent protein. Gene, 111 (2), 229–233. DOI: 10.1016/0378-1119 (92) 90691-H 2. Tsien, R. Y. (1998) . The green fluorescent protein. Annual Review of Biochemistry, 67 (1), 509–544. DOI: 10.1146/annurev.biochem.67.1.509 3. Bradbury, A., & Plückthun, A. (2015) . Reproducibility: Standardize antibodies used in research. Nature, 518 (7537), 27–29. DOI: 10.1038/518027a