Slo1 (BK Channel, KCNMA1) Antibody, Clone S22: APC

Slo1, also known as the BK (Big Potassium) channel or BKα, is a voltage- and calcium-activated potassium channel highly expressed in neurons and smooth muscle. It plays a critical role in regulating membrane excitability by facilitating the repolarization phase of action potentials and modulating neurotransmitter release. Slo1 channel activity is finely tuned by intracellular Ca²⁺ levels and membrane potential, and is further regulated by auxiliary KCNMB subunits. This dynamic regulation enables Slo1 to influence synaptic transmission, motor coordination, and responses to ethanol. Notably, Slo1 dysfunction has been implicated in a range of neurological and neuromuscular disorders, including epilepsy, ataxia, hypertension, and muscular dystrophy. Recent studies suggest that Slo1 may also contribute to neurodegenerative disease mechanisms by altering neuronal firing patterns and calcium homeostasis. Its interaction with dystrophin-related pathways further underscores its relevance in neuromuscular integrity. Given its broad physiological roles and disease associations, Slo1 is emerging as a promising target for therapeutic intervention and biomarker development in neurodegenerative research.

Slo1, BKAlpha, maxi-K+ channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, Subfamily M subunit alpha-1, KCa1.1, K (VCA) alpha, BK channel, BKCA alpha, Maxi K channel, Slo-alpha, Slowpoke homolog, Kcnma1, Kcnma, Maxi Potassium channel alpha, KCMA1, Slo, BKCa, mSlo, MaxiK, mSlo1, 5730414M22Rik, BK, BKCA channel, K VCA, BKCA alpha subunit, BKTM, Drosophila slowpoke like, SAKCA

WB (1:1000), IHC (1:100), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.; optimal dilutions for assays should be determined by the user.

1. Yang, C.T., Zeng X.H., Xia X.M., and Lingle C.J. (2009) . Interactions between β Subunits of the KCNMB Family and Slo3: β4 Selectively Modulates Slo3 Expression and FunctionPloS One. 4 (7) : e6135. DOI: 10.1371/journal.pone.0006135 2. Latorre, R., & Brauchi, S. (2006) . Large conductance Ca2+-activated K+ (BK) channel: Activation by Ca2+ and voltage. Biological Research, 39 (3), 385-401. DOI: 10.4067/s0716-97602006000300003 3. Petkov G. V. (2014) . Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology. American journal of physiology. Regulatory, integrative and comparative physiology, 307 (6), R571–R584. DOI: 10.1152/ajpregu.00142.2014 4. Pathak, D., Guan, D., & Foehring, R. C. (2016) . Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex. Journal of neurophysiology, 115 (5), 2317–2329. DOI: 10.1152/jn.01028.2015 5. Kim, H., Pierce-Shimomura, J. T., Oh, H. J., Johnson, B. E., Goodman, M. B., & McIntire, S. L. (2009) . The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans. PLoS genetics, 5 (12), e1000780. DOI: 10.1371/journal.pgen.1000785