CaCCinh-A01

CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively.

Product Specifications

CAS Number

[407587-33-1]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/CaCCinh-A01.html

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(NC(C2=CC=CO2)=O)SC3=C1CCC(C(C)(C)C)C3)O

Molecular Formula

C18H21NO4S

Molecular Weight

347.43

Precautions

H317, H319

References & Citations

[1]TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloridechannel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286 (3) :2365-74.|[2]De La Fuente R, et al. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloridechannel. Mol Pharmacol. 2008 Mar;73 (3) :758-68.|[3]Pin-Yi Liu, et al. TMEM16A Inhibition Preserves Blood-Brain Barrier Integrity After Ischemic Stroke.Front Cell Neurosci. 2019 Aug 6;13:360.