4,4'-Sulfonyldiphenol

4,4'-Sulfonyldiphenol (Bisphenol S; Bis (4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[80-09-1]

Product Name Alternative

Bisphenol S; Bis (4-hydroxyphenyl) sulfone

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Akt; Androgen Receptor; Estrogen Receptor/ERR; Histone Methyltransferase; mTOR; PI3K; Thyroid Hormone Receptor

Type

Biochemical Assay Reagents

Related Pathways

Epigenetics; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Endocrinology; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/4-4-sulfonyldiphenol.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(O)C=C1)(C2=CC=C(O)C=C2)=O

Molecular Formula

C12H10O4S

Molecular Weight

250.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Kolla S, et al. Bisphenol S alters development of the male mouse mammary gland and sensitizes it to a peripubertal estrogen challenge. Toxicology. 2019 Aug 1;424:152234. |[2]Ivry Del Moral L, et al. Obesogen effects after perinatal exposure of 4,4'-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice. Toxicology. 2016 May 16;357-358:11-20.|[3]Zhang YF, et al. Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo. Environ Pollut. 2018 Jun;237:1072-1079. |[4]Li S, et al. Bisphenol S Exposure and MASLD: A Mechanistic Study in Mice. Environ Health Perspect. 2025 May;133 (5) :57009.|[5]Kolla S, et al. Bisphenol S alters development of the male mouse mammary gland and sensitizes it to a peripubertal estrogen challenge. Toxicology. 2019 Aug 1;424:152234.|[6]Ko MY, et al. Bisphenol S (BPS) induces glioblastoma progression via regulation of EZH2-mediated PI3K/AKT/mTOR pathway in U87-MG cells. Toxicology. 2024 Sep;507:153898. |[7]Wang W, et al. Bisphenol S exposure accelerates the progression of atherosclerosis in zebrafish embryo-larvae. J Hazard Mater. 2022 Mar 15;426:128042.