1-Formyl-beta-carboline
1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV) . 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway[1].
Product Specifications
CAS Number
20127-63-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; Influenza Virus
Type
Natural Products
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/1-formyl-beta-carboline.html
Purity
99.70
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
C1=CC=C2C(=C1)C3=C(C(=NC=C3)C=O)N2
Molecular Formula
C12H8N2O
Molecular Weight
196.21
Precautions
H302, H315, H319, H335
References & Citations
[1]1-Formyl- β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes
Shipping Conditions
Room Temperature
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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