EGCG Octaacetate

EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG) . EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB) . EGCG Octaacetate exhibits antioxidant, anti-angiogenesis, anti-inflammatory and antitumor activities[1][2][3].

Product Specifications

CAS Number

[148707-39-5]

Product Name Alternative

AcEGCG; Peracetylated (-) -epigallocatechin-3-gallate

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Akt; Bacterial; NF-κB; PI3K

Type

Reference compound

Related Pathways

Anti-infection; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/egcg-octaacetate.html

Purity

98.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(OC(C)=O)=C(C(OC(C)=O)=C1)OC(C)=O)O[C@H]2[C@](C3=CC(OC(C)=O)=C(C(OC(C)=O)=C3)OC(C)=O)([H])OC4=CC(OC(C)=O)=CC(OC(C)=O)=C4C2

Molecular Formula

C38H34O19

Molecular Weight

794.67

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Wang CC, et al. Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Angiogenesis. 2013 Jan;16 (1) :59-69.|[2]KalaiselviIgnasimuthu, et al. Enhanced bioaccessibility of green tea polyphenols and lipophilic activity of EGCG octaacetate on gram-negative bacteria. Volume 105, May 2019, Pages 103-109.|[3]Yi-Shiou Chiou, et al. Peracetylated (-) -epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J Agric Food Chem. 2012 Apr 4;60 (13) :3441-51.|[4]Lambert JD, et al., Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate. Drug Metab Dispos. 2006 Dec;34 (12) :2111-6.