TPO agonist 1
TPO agonist 1 is a thrombopoietin (TPO) agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia[1].
Product Specifications
CAS Number
[1033040-23-1]
UNSPSC
12352005
Hazard Statement
H228, H301
Target
Thrombopoietin Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/TPO-agonist-1.html
Purity
98.0
Solubility
DMSO : ≥ 36 mg/mL
Smiles
O=C(N(C1=CC=C(C)C(C)=C1)N=C/2C)C2=N\NC3=C(O)C(C4=CC=CC(C5=NN=NN5)=C4)=CC=C3
Molecular Formula
C25H22N8O2
Molecular Weight
466.49
Precautions
H228, H301
References & Citations
[1]Jerome Francis Hayes. Novel processes of making hydroxy-1-azo-derivatives as tpo mimetics. 6 November 2008. WO2008134338A1.|[2]Siegal D et al. Thrombopoietin receptor agonists in primary immune thrombocytopenia.
 et al. Semin Hematol. 2013 Jan;50 Suppl 1:S18-21
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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