TPO agonist 1

TPO agonist 1 is a thrombopoietin (TPO) agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia[1].

Product Specifications

CAS Number

[1033040-23-1]

UNSPSC

12352005

Hazard Statement

H228, H301

Target

Thrombopoietin Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/TPO-agonist-1.html

Purity

98.0

Solubility

DMSO : ≥ 36 mg/mL

Smiles

O=C(N(C1=CC=C(C)C(C)=C1)N=C/2C)C2=N\NC3=C(O)C(C4=CC=CC(C5=NN=NN5)=C4)=CC=C3

Molecular Formula

C25H22N8O2

Molecular Weight

466.49

Precautions

H228, H301

References & Citations

[1]Jerome Francis Hayes. Novel processes of making hydroxy-1-azo-derivatives as tpo mimetics. 6 November 2008. WO2008134338A1.|[2]Siegal D et al. Thrombopoietin receptor agonists in primary immune thrombocytopenia. et al. Semin Hematol. 2013 Jan;50 Suppl 1:S18-21