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ERRα antagonist-1

ERRα antagonist-1 (Compound A) is a selective and high affinity agonist for estrogen-related receptor α (ERRα) . ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively[1].

Product Specifications

CAS Number

1072145-33-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/err-alpha-antagonist-1.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=CC=CC=C1C(/N=C3SCCN\3C4=NCCS4)C5=CC=CC=C5C=C2

Molecular Formula

C21H19N3S2

Molecular Weight

377.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERRα

Available Sizes

Frequently Asked Questions

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