ERRα antagonist-1
ERRα antagonist-1 (Compound A) is a selective and high affinity agonist for estrogen-related receptor α (ERRα) . ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively[1].
Product Specifications
CAS Number
[1072145-33-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/err-alpha-antagonist-1.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C12=CC=CC=C1C(/N=C3SCCN\3C4=NCCS4)C5=CC=CC=C5C=C2
Molecular Formula
C21H19N3S2
Molecular Weight
377.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERRα
Available Sizes
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