Recombinant Human Tumor necrosis factor receptor superfamily member 1B protein (TNFRSF1B) (Active)

Receptor with high affinity for TNFSF2, TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1, lymphotoxin-alpha. The TRAF1, TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B, TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. {ECO:0000269|PubMed:12370298}.

M+PAQVAFTPY APEPGSTCRL REYYDQTAQM CCSKCSPGQH AKVFCTKTSD TVCDSCEDST YTQLWNWVPE CLSCGSRCSS DQVETQACTR EQNRICTCRP GWYCALSKQE GCRLCAPLRK CRPGFGVARP GTETSDVVCK PCAPGTFSNT TSSTDICRPH QICNVVAIPG NASMDAVCTS TSPT

Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 0.2 g, ml, corresponding to a specific activity of 5000 IU, mg in the presence of 0.25 ng, mL of rHuTNF-α .

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.