Ribociclib succinate hydrate
Ribociclib succinate hydrate (LEE011 succinate hydrate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
Product Specifications
CAS Number
[1374639-79-8]
Product Name Alternative
LEE011 (succinate hydrate)
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H372, H400
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LEE011-succinate-hydrate.html
Purity
99.94
Solubility
DMSO : ≥ 20 mg/mL|H2O : 4 mg/mL (ultrasonic)
Smiles
O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5.OC(CCC(O)=O)=O.[xH2O]
Molecular Formula
C23H30N8O.C4H6O4.xH2O
Precautions
H301, H315, H319, H372, H400
References & Citations
[1]VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21 (13) :2905-10.|[2]Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19 (22) :6173-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CDK4; CDK6
Citation 01
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